目的系统评价儿童心理应激对青春期情绪行为问题的影响。方法计算机检索PubMed、OVID、EBSCO、Web of Science、CBM、VIP、WanFang Data和CNKI数据库,搜集儿童心理应激对青春期情绪行为问题影响的研究,检索时限均从建库至2024年2月29日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用定性分析方法进行归纳总结。结果共纳入41项队列研究,19项研究的结局指标涉及青春期情绪问题,26项研究涉及行为问题,7项研究涉及整体问题。系统评价结果显示:抑郁(14/19)和焦虑(8/19)是报告较多的情绪行为,大多数研究(17/19)表明儿童心理应激对青春期情绪问题有正向预测作用;涉及的行为问题较多,包括吸烟行为、饮酒行为、违法物质使用、自伤行为、自杀行为、外化行为、犯罪行为、霸凌行为、性行为、手机依赖等,但研究相同行为问题的研究较少,研究内容分散,儿童心理应激与各行为问题的关系尚不明确。结论儿童心理应激可能对青春期抑郁和焦虑有正向预测作用,但儿童心理应激与青春期其他情绪问题及行为问题的关系尚待进一步研究。
本研究采用孟德尔随机化分析探讨精神疾病与胃肠道疾病风险之间的因果关系。利用精神基因组学联盟(PGC)的GWAS数据,选取精神分裂症、重度抑郁症、双相情感障碍和创伤后应激障碍(PTSD)相关的SNP作为工具变量,并结合IEU数据库的胃肠道疾病数据,分析其对胃食管反流病(GERD)、胃溃疡、十二指肠溃疡和慢性胃炎的影响。结果显示,重度抑郁症显著增加GERD (OR = 1.505, P = 2.57 × 10−13)和胃溃疡(OR = 1.294, P = 1.48 × 10−4)的风险,而PTSD也增加了GERD的风险(OR = 1.180, P = 0.003),但其他精神疾病与胃肠道疾病之间未发现显著相关性。本研究揭示了重度抑郁症和PTSD对GERD的潜在致病作用,同时发现重度抑郁症可能增加胃溃疡的风险,为精神疾病患者的胃肠道健康管理提供了新的科学依据。This study utilized Mendelian randomization analysis to explore the causal relationship between psychiatric disorders and the risk of gastrointestinal (GIT) diseases. GWAS data from the Psychiatric Genomics Consortium (PGC) were used, selecting SNPs associated with schizophrenia, major depressive disorder, bipolar disorder, and post-traumatic stress disorder (PTSD) as instrumental variables. GIT disease data were obtained from the IEU database to analyze their effects on gastroesophageal reflux disease (GERD), gastric ulcer, duodenal ulcer, and chronic gastritis. The results showed that major depressive disorder significantly increased the risk of GERD (OR = 1.505, P = 2.57 × 10−13) and gastric ulcers (OR = 1.294, P = 1.48 × 10−4), while PTSD also increased the risk of GERD (OR = 1.180, P = 0.003). However, no significant association was found between other psychiatric disorders and GIT diseases. This study highlights the potential pathogenic role of major depressive disorder and PTSD in GERD and suggests that major depressive disorder may also increase the risk of gastric ulcers, providing new scientific evidence for the gastrointestinal health
