目的对比达格列净、维格列汀、阿卡波糖对新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者骨代谢影响。方法选定医院2018年9月—2019年3月住院治疗的120例新诊断T2DM患者,根据“随机数字表法”分组,A组40例患者采纳达格列净+二甲双胍治疗,B组40例患者采纳维格列汀+二甲双胍治疗,C组40例患者采纳阿卡波糖+二甲双胍治疗,比较三组临床疗效、血糖指标、胰岛功能指标、血清Ⅰ型原胶原氨基端肽(N-terminal propeptide of typeⅠprecollagen,P1NP)、血清Ⅰ型胶原羧基末端肽(βcross-linked C-telopeptide of type I collagen,β-CTX)水平、不良反应发生率。结果A组总有效率(95.00%)与B组(92.50%)、C组(87.50%)比较,P>0.05。A组治疗后空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2 h blood glucose after meal,2 hPG)、胰岛素抵抗指数(homeostasis model assessment,HOMA-IR)、胰岛β细胞功能指数(homeostasis model assessment-β,HOMA-β)与B组、C组比较,P>0.05。B组、C组治疗后血清P1NP、β-CTX均低于A组,P<0.05,B组血清P1NP、β-CTX水平与C组比较,P>0.05。A组不良反应发生率(5.00%)与B组(2.50%)、C组(7.50%)比较,P>0.05。结论达格列净、维格列汀、阿卡波糖均可有效降低新诊断T2DM患者血糖,改善胰岛功能,但维格列汀、阿卡波糖可有效降低血清P1NP、β-CTX水平,预防骨质疏松。
目的:探讨正常糖耐量组(NGT组)与糖尿病前期组(IGT组)多囊卵巢综合征(PCOS)患者内脏脂肪含量与其糖代谢、胰岛素抵抗(IR)的相关性。方法:回顾性收集2021年1月至2024年6月诊治的65例PCOS患者的临床资料,根据血糖情况分为NGT组和IGT组,其中NGT组31例,IGT组34例。比较2组临床资料、肥胖指标水平,分析比较BMI、SAT、VAT对IR的影响程度及预测价值。结果:两组的年龄、PCOS表型、月经周期、FINS、TG、LDL-C、FSH、T、SAT差异均无统计学意义(P > 0.05)。IGT组的FPG、HOMA-1R、TC、BMI、VAT均高于NGT组(P 2。结论:VAT高的PCOS更容易出现糖代谢紊乱、IR,VAT对IR具有一定的预测价值。Objective: To investigate the correlation between visceral fat content, glucose metabolism and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) in normal glucose tolerance group (NGT group) and impaired glucose tolerance group (IGT group). Methods: Collected the clinical data of 65 PCOS patients diagnosed and treated in Longgang District Central Hospital of Shenzhen from 2021 to 2024, and divided them into hyperglycemia PCOS group (NGT-group) 31 cases and orthoglycemic PCOS group (IGT-group) 34 cases. Compare the two groups of clinical data, obesity index level, analyze and compare the influence degree and predictive value of BMI, VAT and SAT on IR. Results: The difference of age, PCOS phenotype, menstrual cycle, FINS, TG, LDL-C, FSH, T, SAT between the two PCOS group were not statistically significant (P > 0.05). The FPG, HOMA-1R, TC, BMI, VAT of the IGT-group were significantly higher than those of NGT-group (P 2. Conclusion: PCOS patients with high visceral fat content are more likely to have glucose metabolism disorders and insulin resistance, VAT has a certain predictive value for IR.
