脂肪酸代谢主要包括脂肪酸氧化(fatty acid oxidation, FAO)和脂肪酸合成,脂肪酸代谢的改变会影响心脏的结构和功能,其作用主要体现在心肌能量供应的改变上。既往研究表明,在心力衰竭状态下,心肌中的能量代谢发生显著变化,其中脂肪酸氧化的变化是研究的重点之一。因此本综述回顾了现有文献,深入探讨脂肪酸代谢与心力衰竭之间的相关性,为其临床防治提供新的线索与思路。Fatty acid metabolism mainly includes fatty acid oxidation (FAO) and fatty acid synthesis. The change of fatty acid metabolism will affect the structure and function of the heart, and its effect is mainly reflected in the change of myocardial energy supply. Previous studies have shown that in the state of heart failure, the energy metabolism in the heart muscle changes significantly, among which the change of fatty acid oxidation is one of the key points of the study. Therefore, this paper reviews the existing literature, deeply explores the correlation between fatty acid metabolism and heart failure, and provides new clues and ideas for its clinical prevention and treatment.
